CRESCENDO is a Transdisciplinary Doctoral Program in Microbiome Science co-funded by the EU (Call  H2020-MSCA-COFUND-2020) and managed by the University of Naples Federico II through its recently established Task Force on Microbiome Studies (www.tfm.unina.it), that combines facilities and experience of more than 150 Academic scientists from 14 different UNINA Departments in the areas of Biology, Medicine, Food and Agricultural Sciences, Chemistry, Pharmacy, Engineering and Social Sciences, thus representing an ideal transdisciplinary environment to support training and research for young researchers in the microbiome field. CRESCENDO Doctoral Programme will recruit 10 international Early Stage Researchers (ESRs-PhDs) who will be involved in research and training in the Microbiome field, leading to a worldwide appreciated PhD degree valuable in terms of their future career perspectives. CRESCENDO represents the only EU funded project for a doctoral programme in Microbiome Science, developing trans-disciplinary Microbiome scientists with intersectoral and international experience and with a multidisciplinary scientific and technical background.